A brute force dichotomization approach to quantitative trait linkage analysis

Authors

  • Julia N. Bailey,

    Corresponding author
    1. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut
    • Yale University Child Study Center, 230 South Frontage Road, New Haven, CT 06510

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  • Laura Almasy

    1. Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
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Abstract

The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed. © 1995 Wiley-Liss, Inc.

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