An investigation to determine whether clusters of cancer types exist in nine breast-ovary families

Authors

  • A. Bansal,

    Corresponding author
    1. School of Mathematics and Statistics, University of Sheffield, Sheffield, United Kingdom
    • School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, United Kingdom

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  • D. T. Bishop,

    1. Genetic Epidemiology Laboratory, Imperial Cancer Research Fund, Ashley Wing, St James's University Hospital, Leeds, United Kingdom
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  • C. Cannings

    1. School of Mathematics and Statistics, University of Sheffield, Sheffield, United Kingdom
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Abstract

Monte-Carlo simulations were carried out on nine BRCA1-linked families selected from the 1993 Breast Cancer Linkage Consortium. These families all displayed a prevalence of both breast and ovarian cancers, but little evidence was found to conclude that sufferers of either type formed clusters in particular branches of families. It was noted that the application of these methods to larger pedigrees with known probands would be useful in further clarifying the issue. © 1995 Wiley-Liss, Inc.

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