Variability of genotype-specific penetrance probabilities in the calculation of risk support intervals

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Abstract

Previously, a maximum likelihood method was described to construct a support interval for the risk. This method is extended to incorporate genotype specific penetrance probabilities in the calculation of a risk support interval. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred. © 1995 Wiley-Liss, Inc.

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