Detection of genome similarity as an exploratory tool for mapping complex traits


  • Dr. Sun-Wei Guo

    Corresponding author
    1. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
    • Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029

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For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical by descent (IBD) conditional on observed marker data. These results can be generalized to multitrait-locus models. Thus, we can use conditional probability of genes shared IBD as a tool to reveal chromosomal segments that are likely to harbor the genes underlying the complex traits. © 1995 Wiley-Liss, Inc.