Tag SNPs chosen from HapMap perform well in several population isolates

Authors

  • Susan Service,

    1. Center for Neurobehavioral Genetics, University of California, Los Angeles, California
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  • Chiara Sabatti,

    1. Department of Human Genetics, University of California, Los Angeles, California
    2. Department of Statistics, University of California, Los Angeles, California
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  • Nelson Freimer

    Corresponding author
    1. Center for Neurobehavioral Genetics, University of California, Los Angeles, California
    2. The Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California
    3. Department of Psychiatry, University of California, Los Angeles, California
    • UCLA Center for Neurobehavioral Genetics, Gonda Center, Room 3506, 695 Charles E Young Drive South, Box 951761, Los Angeles CA 90095-1761
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Abstract

Population isolates may be particularly useful for association studies of complex traits. This utility, however, largely depends on the transferability of tag SNPs chosen from reference samples, such as HapMap, to samples from such populations. Factors that characterize population isolates, such as widespread genetic drift, could impede such transferability. In this report, we show that tag SNPs chosen from HapMap perform well in several population isolates; this is true even for populations that differ substantially from the HapMap sample either in levels of linkage disequilibrium or in SNP allele frequency distributions. Genet. Epidemiol. 2007. © 2007 Wiley-Liss, Inc.

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