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Original Article
Gene by environment interactions
Article first published online: 28 NOV 2007
DOI: 10.1002/gepi.20282
© 2007 Wiley-Liss, Inc.
Issue
Genetic Epidemiology
Supplement: Genetic Analysis Workshop 15: Summaries of the Design and Analysis of Genomic Data
Volume 31, Issue S1, pages S68–S74, 2007
Additional Information
How to Cite
Culverhouse, R. C. and Suarez, B. K. (2007), Gene by environment interactions. Genet. Epidemiol., 31: S68–S74. doi: 10.1002/gepi.20282
Publication History
- Issue published online: 28 NOV 2007
- Article first published online: 28 NOV 2007
Funded by
- The National Institute of Health. Grant Number: K25-GM069590
- Abstract
- References
- Cited By
Keywords:
- linkage;
- association;
- methods;
- rheumatoid arthritis
Abstract
This paper summarizes the contributions of group 8 to the Genetic Analysis Workshop 15. Group 8 focused on ways to address the possibility that genetic and environmental effects on phenotype may not be independent, but instead may interact in ways that could play important roles in determining phenotype. Among the eight contributors to this group, all three data sets (expression data, rheumatoid arthritis data, and simulated data) were analyzed. Contributions to this section fell into the two broad categories of refining the data (e.g. stratifying or weighting based on a covariate value) and explicitly modeling the interactions. The contributions also illustrate that there are at least two possible goals for such studies. One goal is simply to identify factors contributing to phenotype in the presence of interactions that might mask the signal to univariate methods. A related but distinct goal is to characterize an interaction (e.g. to determine if the interaction is significant). Genet. Epidemiol. 31(Suppl. 1):S68–S74, 2007. © 2007 Wiley-Liss, Inc.