A complete list of Group 14 primary contributing authors is given in the Acknowledgment section.
Multistage designs in the genomic era: Providing balance in complex disease studies
Article first published online: 28 NOV 2007
© 2007 Wiley-Liss, Inc.
Supplement: Genetic Analysis Workshop 15: Summaries of the Design and Analysis of Genomic Data
Volume 31, Issue S1, pages S118–S123, 2007
How to Cite
Dubé, M.-P., Schmidt, S. and Hauser, E. (2007), Multistage designs in the genomic era: Providing balance in complex disease studies. Genet. Epidemiol., 31: S118–S123. doi: 10.1002/gepi.20288
- Issue published online: 28 NOV 2007
- Article first published online: 28 NOV 2007
- NIH. Grant Numbers: MH59528, EY015216
- Neurosciences Education and Research Foundation
- Fonds de la recherche en santé du Québec
- two-stage study design;
- joint analysis;
- statistical power;
- genetic association
In this summary paper, we describe the contributions included in the Multistage Design group (Group 14) at the Genetic Analysis Workshop 15, which was held during November 12–14, 2006. Our group contrasted and compared different approaches to reducing complexity in a genetic study through implementation of staged designs. Most groups used the simulated dataset (problem 3), which provided ample opportunities for evaluating various staged designs. A wide range of multistage designs that targeted different aspects of complexity were explored. We categorized these approaches as reducing phenotypic complexity, model complexity, analytic complexity or genetic complexity. In general we learned that: (1) when staged designs are carefully planned and implemented, the power loss compared to a single-stage analysis can be minimized and study cost is greatly reduced; (2) a joint analysis of the results from each stage is generally more powerful than treating the second stage as a replication analysis. Genet. Epidemiol. 31 (Suppl. 1):S118–S123, 2007. © 2007 Wiley-Liss, Inc.