Haplotype-based analysis: a summary of GAW16 Group 4 analysis
Article first published online: 18 NOV 2009
© 2009 Wiley-Liss, Inc.
Supplement: Genetic Analysis Workshop 16: Approaches to Analysis of Genome-Wide Data
Volume 33, Issue Supplement 1, pages S24–S28, 2009
How to Cite
Hauser, E., Cremer, N., Hein, R. and Deshmukh, H. (2009), Haplotype-based analysis: a summary of GAW16 Group 4 analysis. Genet. Epidemiol., 33: S24–S28. doi: 10.1002/gepi.20468
- Issue published online: 18 NOV 2009
- Article first published online: 18 NOV 2009
- NIH. Grant Numbers: R01 GM031575, R01 MH59528
- Neurosciences Education and Research Foundation
- population stratification;
- multiple comparisons
In this summary article, we describe the contributions included in the haplotype-based analysis group (Group 4) at the Genetic Analysis Workshop 16, which was held in September 17–20, 2008. Our group applied a large number of haplotype-based methods in the context of genome-wide association studies. Two general approaches were applied: a two-stage approach that selected significant single-nucleotide polymorphisms (SNPs) in the first stage and then created haplotypes in the second stage and genome-wide analysis of smaller sets of SNPs selected by sliding windows or estimating haplotype blocks. Genome-wide haplotype analyses performed in these ways were feasible. The presence of the very strong chromosome 6 association in the North American Rheumatoid Arthritis Consortium data was detected by every method, and additional analyses attempted to control for this strong result to allow detection of additional haplotype associations. Genet. Epidemiol. 33 (Suppl. 1):S24–S28, 2009. © 2009 Wiley-Liss, Inc.