Distribution of model-based multipoint heterogeneity lod scores



The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution equation image, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. Genet. Epidemiol. 34: 912-916, 2010.© 2010 Wiley-Liss, Inc.