Original Article

You have free access to this content

On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations

  1. Christoph Lange*,
  2. Nan M. Laird

Article first published online: 3 SEP 2002

DOI: 10.1002/gepi.209

Issue

Genetic Epidemiology

Genetic Epidemiology

Volume 23, Issue 2, pages 165–180, August 2002

Additional Information

How to Cite

Lange, C. and Laird, N. M. (2002), On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet. Epidemiol., 23: 165–180. doi: 10.1002/gepi.209

Author Information

  1. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts

*Department of Biostatistics, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115

Publication History

  1. Issue published online: 3 SEP 2002
  2. Article first published online: 3 SEP 2002
  3. Manuscript Accepted: 10 APR 2002
  4. Manuscript Received: 5 FEB 2002

Funded by

  • NIH. Grant Numbers: MH59532, HL66383
  • NHLBI. Grant Number: NOI HR16040

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (208K)

REFERENCES

  • Allison DB. 1997. Transmission-disequilibrium tests for quantitive traits. Am J Hum Genet 60:676–90.
  • Allison DB, Heo M, Kaplan N, Martin ER. 1999. Sibling-based tests of linkage and association for quantitive traits. Am J Hum Genet 64:1754–64.
  • Balding D, Bishop M, Cannings C. 2001. Handbook of statistical genetics. New York: John Wiley.
  • Billingsley P. 1995. Probability and measure. New York: John Wiley.
  • Boehnke M, Langefeld CD. 1998. Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am J Hum Genet 62:950–61.
  • Clayton D. 2001. Population association. In: BaldingD, BishopM, CanningsC. Handbook of statistical genetics. New York: John Wiley. p 519–40.
  • Cox DR, Hinkley DV. 1979. Theoretical statistics. New York: Chapman and Hall.
  • Falconer DS, Mackay TFC. 1997. Introduction to quantitative genetics. Longman.
  • Horvath S, Laird NM. 1998. A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am J Hum Genet 63:1886–97.
  • Horvath S, Laird N. 2002. Family-based association tests involving quantitative traits. In: Encyclopedia of Hum Genet and Genet Epidemiol.
  • Horvath S, Xu X, Laird N. 2001. The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301–6.
  • Laird N, Horvath S, Xu X. 2000. Implementing a unified approach to family based tests of association. Genet Epidemiol [Suppl] 19:36–42.
    Direct Link:
  • Lake S, Blacker D, Laird N. 2000. Family-based tests of association in the presence of linkage. Am J Hum Genet 67:1515–25.
  • Lange C, Laird NM. 2002. Power calculations for a general class of family-based association tests. AJHG [In press].
  • Lange C, Silverman E, Weiss S, Xu X, Laird N. 2001. A multivariate transmission disequilibrium test. Biostatistics [In press].
  • Lazzeroni L, Lange K. 2001. A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered 48:67–81.
  • Lunetta K, Faraone S, Biederman J, Laird N. 2000. Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. Am J Hum Genet 66:605–14.
  • McGinnis R. 2000. General equations for pt, ps, and the power of the tdt and the affected sib-pair test. Am J Hum Genet 67:1340–7.
  • Petrov V. 1995. Sums of independent random variables. Berlin: Springer.
  • Rabinowitz D. 1997. A transmission disequilibrium test for quantitative trait loci. Hum Hered 47:1113–8.
  • Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211–23.
  • Risch N. 2000. Searching for genetic determinants in the new millennium. Nature 405:847–56.
  • Serfling R. 1980. Approximation theorems of mathematical statistics. New York: Wiley.
  • Sham P. 1997. Statistics in human genetics. Arnold.
  • Spielman R, McGinnis R, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (iddm). Am J Hum Genet 52:506–16.
  • Whittemore A, Tu I. 2000, Detection of disease genes by use of family data. Likelihood-based theory. Am J Hum Genet 66:1328–40.
  • Yang Q, Xu X, Laird N. fficient sampling designs for family-based test of association studies.
Get PDF (208K)