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Table S1. Distribution of CPD and demographics in participating samples

Table S2. Single SNP association with heavy vs. light smoking for Bin A variants (r2 with rs16969968 or rs1051730 ≥0.70 in CEU 1000 Genome Pilot 1) in Asians and African American ancestry (Bin A rs16969968, OR = 1.31, 95% CI = 1.22–1.40, P = 1.31 × 10-14 in European ancestry samples)

Table S3. Conditional analyses (controlling for Bin A SNP rs16969968) with heavy vs. light smoking for Bin B variants (r2 with rs880395 or rs588765 ≥0.70 in CEU 1000 Genome Pilot 1) in Asians and African American ancestry (Bin B conditional analysis OR = 1.27, 95% CI = 1.16–1.38, P = 8.66E-08 in European ancestry samples)

Table S4. Conditional analyses (controlling for Bin A SNP rs16969968) with heavy vs. light smoking for Bin C variants (r2 with rs6495308, rs2036534, rs7163730, rs9788682, rs684513, rs578776 ≥0.70 in CEU 1000 Genome Pilot 1) in Asians and African American ancestry (Bin C conditional analysis OR = 0.79, 95% CI = 0.72–0.86, P = 2.47 × 10-07 in European ancestry samples)

Table S5. Conditional analyses with heavy vs. light smoking for Bin D variants (r2 with rs2869046 ≥0.70 in CEU 1000 Genome Pilot 1) in Asians and African American ancestry (Bin D conditional analysis OR = 0.99, 95% CI = 0.90–1.10, P = 0.92 in European ancestry samples)

Table S6. Single SNP association with heavy vs. light smoking for Bin B variants (r2 with rs880395 and rs588765 ≥0.70 in CEU 1000 Genome Pilot 1) in Asians and African American ancestry (Bin B single SNP association OR = 1.00, 95% CI = 0.94–1.07, P = 0.99 in European ancestry samples)

Table S7. Single SNP association with heavy vs. light smoking for Bin C variants (r2 with rs6495308, rs2036534, rs7163730, rs9788682, rs684513, rs578776 ≥0.70 in CEU 1000 Genome Pilot 1) in Asians and African American ancestry (Bin C single SNP association OR = 0.77, 95% CI = 0.71-0.83, P = 3.95 × 10-11 in European ancestry samples)

Table S8. Single SNP association with heavy vs. light smoking for Bin D variants (r2 with rs2869046 ≥0.70 in CEU 1000 Genome Pilot 1) in Asian and African American ancestry (Bin D single SNP association OR = 1.01, 95% CI = 0.93–1.10, P = 0.80 in European ancestry samples)

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