Contract grant sponsor: Spanish Science and Innovation Ministry Strategic Project; Contract grant numbers: PSE-010000-2006-6, IPT-010000-2010-36.
Unveiling Case-Control Relationships in Designing a Simple and Powerful Method for Detecting Gene-Gene Interactions
Version of Record online: 7 AUG 2012
© 2012 Wiley Periodicals, Inc.
Volume 36, Issue 7, pages 710–716, November 2012
How to Cite
Canela-Xandri, O., Julià, A., Gelpí, J. L. and Marsal, S. (2012), Unveiling Case-Control Relationships in Designing a Simple and Powerful Method for Detecting Gene-Gene Interactions. Genet. Epidemiol., 36: 710–716. doi: 10.1002/gepi.21665
- Issue online: 12 OCT 2012
- Version of Record online: 7 AUG 2012
- Manuscript Accepted: 14 JUN 2012
- Manuscript Revised: 1 JUN 2012
- Manuscript Received: 31 JAN 2012
- Spanish Science and Innovation Ministry Strategic. Grant Numbers: PSE-010000-2006-6, IPT-010000-2010-36
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
|gepi21665-sup-0001-FigureS1.doc||164K||Figure S1 Null distribution computed numerically from 106 replicates of a sample of 2000 cases and 2000 controls. Subplots (A) and (B) are computed under conditions 1 and 2, respectively (see text). The red line represents a chi square distribution with 4 degrees of freedom.|
|gepi21665-sup-0002-FigureS2.doc||100K||Figure S2 Probability-probability density plot for PZ (x axis) and LRIT method (y axis). The color represents the number of tests on a logarithmic scale in each point determined by the P-values obtained by both methods for each data set for the 48 basic epistatic models. Although LRIT is marginally more powerful, it is clear that the performance of both methods is very similar.|
|gepi21665-sup-0003-FigureS3.doc||226K||Figure S3 Probability-probability density plot for the case-only χ2 (x axis) and the case-control 2χ2 method (y axis). The color represents the number of tests on a logarithmic scale in each point determined by the P-values obtained by both methods for each data set for the 48 basic epistatic models. Different prevalences (0.01, 0.05, 0.1, 0.15, 0.2) are colored with different gradient colors. Higher prevalences present higher slope. The simulations are done with 500 cases and 500, 1000, and 1500 controls for subplots (A), (B), and (C), respectively.|
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