Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies


  • Ronglin Che,

  • Alison A. Motsinger-Reif,

    Corresponding author
    • Bioinformatics Research Center,, Department of Statistics, North Carolina State University, Raleigh, North Carolina
    Search for more papers by this author
  • Chad C. Brown

  • Contract grant sponsor: National Institute of General Medical Sciences; Contract grant number: NT32GM081057; Contract grant sponsor: National Institute of Health; Contract grant number: NCI R01 CA161608.

Correspondence to: Alison A. Motsinger-Reif, Bioinformatics Research Center, Department of Statistics, 307 Ricks Hall, 1 Lampe Dr., Raleigh, NC 27695-7566. E-mail: motsinger@stat.ncsu.edu