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Supplementary tables and figures may be found on the online version of this article.

Supplementary Material

Supplementary Table 1 Description and threshold TSK for a type 1 error of 5 × 10−4 using 302 simulated loci for the 4 strategies studied

Supplementary Table 2 Power of the genotypic test to detect at least one causal variant for the different strategies (x100) in samples of 300 trio families

Supplementary Table 3 Power of the allelic test to detect at least one causal variant for the different strategies (x100) in samples of 300 trio families

Supplementary Figure 1 QQplots of nested statistics Qi of the genotypic tests in strategies S3 and S4. Under the null hypothesis, the p-values are uniformly distributed and the quantity –2 log(P-value) follows a chi-square distribution with 2 degrees of freedom.

Supplementary Figure 2 QQplots of the nested statistics Qi of the allelic tests in strategies S3 and S4. Under the null hypothesis, the p-values are uniformly distributed and the quantity –2 log(P-value) follows a chi-square distribution with 2 degrees of freedom.

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