Empirical Bayes Correction for the Winner's Curse in Genetic Association Studies
Article first published online: 25 SEP 2012
© 2012 Wiley Periodicals, Inc.
Volume 37, Issue 1, pages 60–68, January 2013
How to Cite
Ferguson, J. P., Cho, J. H., Yang, C. and Zhao, H. (2013), Empirical Bayes Correction for the Winner's Curse in Genetic Association Studies. Genet. Epidemiol., 37: 60–68. doi: 10.1002/gepi.21683
- Issue published online: 14 DEC 2012
- Article first published online: 25 SEP 2012
- Manuscript Accepted: 17 AUG 2012
- Manuscript Revised: 14 AUG 2012
- Manuscript Received: 24 JUN 2012
- NIH. Grant Numbers: R01 GM59507, U01 DK062429, U01 DK062422, RC1DK086800
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
|gepi21683-sup-0001-FigureS1.tif||1317K||Figure 1: Sensitivity of the Empirical Bayes estimation to the number of bins chosen.|
|gepi21683-sup-0002-FigureS2.tif||2700K||Figure 2: Average Mean Squared error on Simulated Data using a threshold of|
|gepi21683-sup-0003-FigureS3.tif||1056K||Figure 3: Estimated mean square error at different Z-scores|
|gepi21683-sup-0004-FigureS4.tif||2700K||Figure 4: Average Mean Bias|
|gepi21683-sup-0005-FigureS5.tif||92K||Figure 5: Comparison of Empirical Bayes, Conditional Likelihood, and BR-Squared in terms of shrinkage on real GWAS data.|
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