Contract grant sponsor: National Institutes of Health; Contract grant number: HL087699; Contract grant sponsor:The National Heart, Lung, and Blood Institute (NHLBI). Contract grant sponsor: COLCIENCIAS; Contract grant number:680-2009. Contract grant sponsor: Health Research Council. Contract grant sponsor: Caribbean Cardiac Society. Contract grant sponsor: University Hospital of West Indies. Contract grant sponsor: The Cultural Arts Sports and Education (CHASE) Fund. Contract grant sponsor: National Health Fund. Contract grant sponsor:National Health Fund Phase 2, 2007–2008. Contract grant sponsor: Mary Beryl Patch Turnbull Scholar Program. Contract grant sponsor: Brazilian National Research Council (CNPq).
African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations
Article first published online: 2 APR 2013
© 2013 Wiley Periodicals, Inc.
Volume 37, Issue 4, pages 393–401, May 2013
How to Cite
Vergara, C., Murray, T., Rafaels, N., Lewis, R., Campbell, M., Foster, C., Gao, L., Faruque, M., Oliveira, R. R., Carvalho, E., Araujo, M. I., Cruz, A. A., Watson, H., Mercado, D., Knight-Madden, J., Ruczinski, I., Dunston, G., Ford, J., Caraballo, L., Beaty, T. H., Mathias, R. A. and Barnes, K. C. (2013), African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations. Genet. Epidemiol., 37: 393–401. doi: 10.1002/gepi.21702
- Issue published online: 15 APR 2013
- Article first published online: 2 APR 2013
- Manuscript Accepted: 22 NOV 2012
- Manuscript Revised: 21 NOV 2012
- Manuscript Received: 13 JUN 2012
- National Institutes of Health. Grant Number: HL087699
- The National Heart, Lung, and Blood Institute (NHLBI)
- COLCIENCIAS. Grant Number: 680-2009
- Health Research Council
- Caribbean Cardiac Society
- University Hospital of West Indies
- The Cultural Arts Sports and Education (CHASE) Fund
- National Health Fund
- National Health Fund Phase 2, 2007–2008
- Mary Beryl Patch Turnbull Scholar Program
- Brazilian National Research Council (CNPq)
Characterization of genetic admixture of populations in the Americas and the Caribbean is of interest for anthropological, epidemiological, and historical reasons. Asthma has a higher prevalence and is more severe in populations with a high African component. Association of African ancestry with asthma has been demonstrated. We estimated admixture proportions of samples from six trihybrid populations of African descent and determined the relationship between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 237 ancestry informative markers in asthmatics and nonasthmatic controls from Barbados (190/277), Jamaica (177/529), Brazil (40/220), Colombia (508/625), African Americans from New York (207/171), and African Americans from Baltimore/Washington, D.C. (625/757). We estimated individual ancestries and evaluated genetic stratification using Structure and principal component analysis. Association of African ancestry and asthma and tIgE was evaluated by regression analysis. Mean ± SD African ancestry ranged from 0.76 ± 0.10 among Barbadians to 0.33 ± 0.13 in Colombians. The European component varied from 0.14 ± 0.05 among Jamaicans and Barbadians to 0.26 ± 0.08 among Colombians. African ancestry was associated with risk for asthma in Colombians (odds ratio (OR) = 4.5, P = 0.001) Brazilians (OR = 136.5, P = 0.003), and African Americans of New York (OR: 4.7; P = 0.040). African ancestry was also associated with higher tIgE levels among Colombians (β = 1.3, P = 0.04), Barbadians (β = 3.8, P = 0.03), and Brazilians (β = 1.6, P = 0.03). Our findings indicate that African ancestry can account for, at least in part, the association between asthma and its associated trait, tIgE levels.