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FilenameFormatSizeDescription
gepi21771-sup-0001-FigureS1.docx282KFigure S1: Study-specific estimates and meta-analysis of the marginal and the interaction effects of the detected SNPs with the respective environmental variables on breast cancer risk in women from BCAC.
gepi21771-sup-0002-FigureS2.pdf91KFigure S2: Regional LD plot of the identified SNP rs12197388 on chromosome 6. Based on data from the 1000 Genome Project, no SNP (indicated by small diamonds) within 500 kb is in LD (r2 > 0.6, see left axis) with rs12197388 (large dark orange diamond), located in the ARID1B gene (green arrow). The blue line indicates areas of higher recombination rate (see right axis).
gepi21771-sup-0003-FigureS3.pdf69KFigure S3: Regional LD plot of the identified SNP rs10483028 on chromosome 21. Based on data from the 1000 Genome Project, there are several SNPs (smaller orange diamonds) in LD (r2 > 0.6, see left axis) with rs10483028 (large dark orange diamond). There is no known gene located with 200 kb around rs10483028. The blue line indicates areas of higher recombination rate (see right axis).
gepi21771-sup-0004-FigureS4.tif43KFigure S4: USCS Genome Browser graphic of the identified SNP rs10483028 (marked in green) on chromosome 21. Neither rs10483028 itself nor any of the 15 SNPs in high LD (r2 > 0.8) with rs10483028 is located in known regulatory elements, in terms of DNaseI hypersensitivity clusters and H3K27Ac mark, for example.
gepi21771-sup-0005-TableS1.docx28KTable S1. Studies of the Breast Cancer Association Consortium included in analyses
gepi21771-sup-0006-TableS2.docx16KTable S2. Variables with corresponding adjustment variables and restrictions
gepi21771-sup-0007-TableS3.docx59KTable S3. Descriptive Statistics by Case-Control Status and Study
gepi21771-sup-0008-TableS4.docx18KTable S4. a: Results from GxE interaction analysis between 71,527 SNPs and 10 environmental variables in 69,261 women from BCAC, using the Hybrid Two-Step Test.
gepi21771-sup-0009-TableS5.docx15KTable S5. Measures of study heterogeneity from random effects meta-analysis for the interaction and marginal effects of the indentified SNPs.
gepi21771-sup-0010-TableS6.docx16KTable S6. GxE correlation in controls between the identified SNPs and risk factors.

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