Decadal trends of volcanic deformation in the Central Andes Volcanic Zone (CVZ) are identified with Interferometric Synthetic Aperture Radar (InSAR) stacks and time series velocity maps covering an area 19°S–27°S and 66°W–69°W. We combine over 750 ERS and Envisat interferograms from two descending and three ascending tracks. These tracks cover 100,000 km 2 and span 1992–2011. Our analysis extends observations at Cerro Blanco, Uturuncu, and Lazufre volcanic centers and uncovers two previously undocumented deformation centers: Cerro Overo in Northern Chile and Putana Volcano in Southwest Bolivia. Cerro Overo exhibits a transition from steady −0.4 cm/yr deflation to 0.5 cm/yr inflation over several years. Putana Volcano underwent a short-lived episode of uplift between 13 September 2009 and 31 January 2010, with a maximum uplift of 4.0 cm. Cerro Blanco continues −1.0 cm/yr deflation since 1995. Uplift at Lazufre began between 1997 and 2000 and has gradually accelerated to 3.5 cm/yr since 2005. Uturuncu volcano continues 1.0 cm/yr monotonic uplift since 1992 and shows evidence for a broad moat of subsidence surrounding the uplifting region. Four of the nine deformation events in the CVZ are not obviously associated with a particular volcanic edifice. Furthermore, there is significant spatial and temporal variability of these deformation events within a small geographic area.