The Jilongshan skarn Cu–Au deposit is located at the Jiurui ore cluster region in the southwestern part of the Middle–Lower Yangtze River valley metallogenic belt. The region is characterized by NW-, NNW- and EW-trending faults and the mineralization occurs at the contact of lower Triassic carbonate rocks and Jurassic granodiorite porphyry intrusions. The intrusives are characterized by SiO2, K2O, and Na2O concentrations ranging from 61.66 to 67.8 wt.%, 3.29 to 5.65 wt.%, and 2.83 to 3.9 wt.%, respectively. Their A/CNK (A/CNK = n(Al2O3)/[n(CaO) + n(Na2O) + n(K2O)]) ratio, δEu, and δCe vary from 0.77 to 1.17, 0.86 to 1, and 0.88 to 0.96, respectively. The rocks show enrichment in light rare earth elements ((La/Yb)N = 7.61–12.94) and large ion lithophile elements (LILE), and depletion in high field strength elements (HFSE), such as Zr, Ti. They also display a peraluminous, high-K calc-alkaline signature typical of intrusives associated with skarn and porphyry Cu–Au–Mo polymetallic deposits. Laser ablation inductively coupled plasma spectrometry (LA-ICP-MS) zircon U–Pb age indicates that the granodiorite porphyry formed at 151.75 ± 0.70 Ma. A few inherited zircons with older ages (677 ± 10 Ma, 848 ± 11 Ma, 2645 ± 38 Ma, and 3411 ± 36 Ma) suggest the existence of an Archaean basement beneath the Middle–Lower Yangtze River region. The temperature of crystallization of the porphyry estimated from zircon thermometer ranges from 744.3 °C to 751.5 °C, and 634.04 °C to 823.8 °C. Molybdenite Re–Os dating shows that the Jilongshan deposit formed at 150.79 ± 0.82 Ma. The metallogeny and magmatism are correlated to mantle–crust interaction, associated with the subduction of the Pacific Plate from the east. Copyright © 2013 John Wiley & Sons, Ltd.