Cell Biology of Microglia
Role of p38 and p44/42 mitogen-activated protein kinases in microglia
Article first published online: 4 OCT 2002
Copyright © 2002 Wiley-Liss, Inc.
Special Issue: Microglia
Volume 40, Issue 2, pages 175–183, November 2002
How to Cite
Koistinaho, M. and Koistinaho, J. (2002), Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia, 40: 175–183. doi: 10.1002/glia.10151
- Issue published online: 4 OCT 2002
- Article first published online: 4 OCT 2002
- Manuscript Accepted: 1 JUL 2002
- Manuscript Received: 14 FEB 2002
- Sigrid Juselius Foundation, Finland
- brain ischemia;
- Alzheimer's disease
Although microglial cells are thought to play a beneficial role in the regeneration and plasticity of the central nervous system (CNS), recent studies have indicated that at least some molecules released by microglia may be harmful in acute brain insults and neurodegenerative diseases. Therefore, the pathways mediating the synthesis and release of these neurotoxic compounds are of importance. p38 and p44/42 families of mitogen-activated protein kinases (MAPKs) in microglia respond strongly to various extracellular stimuli, such as ATP, thrombin, and β-amyloid, a peptide thought to be responsible for the neuropathology in Alzheimer's disease. In this review we describe in vivo evidence implicating that p38 and p44/42 MAPKs may play a critical role in harmful microglial activation in acute brain injury, such as stroke, and in more chronic neurodegenerative diseases, such as Alzheimer's disease. We also clarify the extracellular signals responsible for activation of p38 and p44/42 MAPK in microglia and review the responses so far reported to be mediated by these kinases. GLIA 40:175–183, 2002. © 2002 Wiley-Liss, Inc.