Microglia as neuroprotective, immunocompetent cells of the CNS
Version of Record online: 4 OCT 2002
Copyright © 2002 Wiley-Liss, Inc.
Special Issue: Microglia
Volume 40, Issue 2, pages 133–139, November 2002
How to Cite
Streit, W. J. (2002), Microglia as neuroprotective, immunocompetent cells of the CNS. Glia, 40: 133–139. doi: 10.1002/glia.10154
- Issue online: 4 OCT 2002
- Version of Record online: 4 OCT 2002
- Manuscript Accepted: 1 JUL 2002
- Manuscript Received: 14 FEB 2002
- microglia-neuron interactions;
- cellular senescence;
- Alzheimer's disease
The role of glial cells is to support and sustain proper neuronal function and microglia are no exception to this. This viewpoint article emphasizes the fundamental interdependence of microglia and neurons and takes a look at the possibility of what could happen if microglial cells became dysfunctional as a result of aging, genetics, or epigenetics. Could microglial senescence be a factor in the pathogenesis of Alzheimer's and other neurodegenerative diseases? The cautious answer to that question is ‘yes’. Future studies along these lines may provide novel insights into microglial involvement in neurodegenerative disease pathogenesis. GLIA 40:133–139, 2002. © 2002 Wiley-Liss, Inc.