Glial modulation of synaptic transmission in the retina
Version of Record online: 8 JUL 2004
Copyright © 2004 Wiley-Liss, Inc.
Special Issue: Glial Control of Synaptic Function
Volume 47, Issue 3, pages 268–274, 15 August 2004
How to Cite
Newman, E. A. (2004), Glial modulation of synaptic transmission in the retina. Glia, 47: 268–274. doi: 10.1002/glia.20030
- Issue online: 8 JUL 2004
- Version of Record online: 8 JUL 2004
- Manuscript Accepted: 19 JAN 2004
- Manuscript Received: 18 DEC 2003
- the National Institutes of Health. Grant Number: EY04077
- Müller cell;
- calcium wave
Glial modulation of synaptic transmission and neuronal excitability in the mammalian retina is mediated by several mechanisms. Stimulation of glial cells evokes Ca2+ waves, which propagate through the network of retinal astrocytes and Müller cells and result in the modulation of the activity of neighboring ganglion cells. Light-evoked spiking is enhanced in some ganglion cells and depressed in others. A facilitation or depression of light-evoked excitatory postsynaptic currents is also seen in ganglion cells following glial stimulation. In addition, stimulation of glial cells evokes a sustained hyperpolarizing current in ganglion cells which is mediated by ATP release from Müller cells and activation of neuronal A1 adenosine receptors. Recent studies reveal that light-evoked activity in retinal neurons results in an increase in the frequency of Ca2+ transients in Müller cells. Thus, there is two-way communication between neurons and glial cells, suggesting that glia contribute to information processing in the retina. © 2004 Wiley-Liss, Inc.