Role of the oligodendroglial cytoskeleton in differentiation and myelination
Article first published online: 19 MAY 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 57, Issue 16, pages 1691–1705, December 2009
How to Cite
Bauer, N. G., Richter-Landsberg, C. and Ffrench-Constant, C. (2009), Role of the oligodendroglial cytoskeleton in differentiation and myelination. Glia, 57: 1691–1705. doi: 10.1002/glia.20885
- Issue published online: 13 OCT 2009
- Article first published online: 19 MAY 2009
- Manuscript Accepted: 25 MAR 2009
- Manuscript Received: 19 DEC 2008
- extracellular matrix;
- signal transduction;
Oligodendrocytes, the myelin-forming cells of the central nervous system, are in culture characterized by an elaborate process network, terminating in flat membranous sheets that are rich in myelin-specific proteins and lipids, and spirally wrap axons forming a compact insulating layer in vivo. By analogy with other cell types, maintenance and stability of these processes, as well as the formation of the myelin sheath, likely rely on a pronounced cytoskeleton consisting of microtubules and microfilaments. While the specialized process of wrapping and compaction forming the myelin sheath is not well understood, considerably more is known about how cytoskeletal organization is mediated by extracellular and intracellular signals and other interaction partners during oligodendrocyte differentiation and myelination. Here, we review the current state of knowledge on the role of the oligodendrocyte cytoskeleton in differentiation with an emphasis on signal transduction mechanisms and will attempt to draw out implications for its significance in myelination. © 2009 Wiley-Liss, Inc.