Functional heterotypic interactions between astrocyte and oligodendrocyte connexins
Article first published online: 2 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 59, Issue 1, pages 26–34, January 2011
How to Cite
Magnotti, L. M., Goodenough, D. A. and Paul, D. L. (2011), Functional heterotypic interactions between astrocyte and oligodendrocyte connexins. Glia, 59: 26–34. doi: 10.1002/glia.21073
- Issue published online: 12 NOV 2010
- Article first published online: 2 NOV 2010
- Manuscript Accepted: 9 AUG 2010
- Manuscript Received: 3 JUN 2010
- NIH. Grant Numbers: RO1 GM37751 (to D.L.P.), RO1 GM18974 (to D.A.G.), P30-HD18655 (to the IDDRC at Children's Hospital, Boston)
- gap junction;
Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligodendrocytes. Because these cell types express nonoverlapping sets of connexins, the intercellular channels formed between them must be asymmetric with regard to connexin content, defined as heterotypic. Here, we show that oligodendrocyte Cx47 can form heterotypic channels with astrocyte Cx43 or Cx30 but not Cx26, whereas oligodendrocyte Cx32 can functionally interact with astrocyte Cx30 or Cx26 but not Cx43. Thus, as many as four types of intercellular channels could be formed between astrocytes and oligodendrocytes. © 2010 Wiley-Liss, Inc.