Original Article

Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity

  1. Ikuko Miyazaki1,
  2. Masato Asanuma1,*,
  3. Yuri Kikkawa1,
  4. Mika Takeshima1,
  5. Shinki Murakami1,
  6. Ko Miyoshi1,
  7. Norio Sogawa2,
  8. Taizo Kita3

Article first published online: 29 DEC 2010

DOI: 10.1002/glia.21112

Issue

Glia

Glia

Volume 59, Issue 3, pages 435–451, March 2011

Additional Information

How to Cite

Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., Miyoshi, K., Sogawa, N. and Kita, T. (2011), Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia, 59: 435–451. doi: 10.1002/glia.21112

Author Information

  1. 1

    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

  2. 2

    Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

  3. 3

    Laboratory of Pharmacology, Kyushu Nutrition Welfare University Graduate School of Food and Nutrition, Kitakyushu, Fukuoka, Japan

*Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan

Publication History

  1. Issue published online: 24 JAN 2011
  2. Article first published online: 29 DEC 2010
  3. Manuscript Accepted: 28 OCT 2010
  4. Manuscript Received: 30 APR 2010

Funded by

  • Grants-in-Aid for Young Scientists (B) and for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology
  • Health and Labour Sciences Research Grants for Research on Measures for Intractable Diseases, for Research on Regulatory Science of Pharmaceuticals and Medical Devices
  • Special Research from the Japanese Ministry of Health, Labour and Welfare
  • Research Grants from Catecholamine and Neurological Diseases Research Foundation, from the Okayama Medial Foundation and from Kawasaki Foundation for Medical Science & Medical Welfare

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (6624K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    N. Lev, Y. Barhum, N. S. Pilosof, D. Ickowicz, H. Y. Cohen, E. Melamed, D. Offen, DJ-1 Protects Against Dopamine Toxicity: Implications for Parkinson's Disease and Aging, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013, 68, 3, 215

    CrossRef

  2. 2
    Ezia Guatteo, Andrew Yee, James McKearney, Maria L. Cucchiaroni, Marta Armogida, Nicola Berretta, Nicola B. Mercuri, Janusz Lipski, Dual effects of l-DOPA on nigral dopaminergic neurons, Experimental Neurology, 2013,

    CrossRef

  3. 3
    Katsura Takano, Nobuyuki Tanaka, Kenji Kawabe, Mitsuaki Moriyama, Yoichi Nakamura, Extracellular Superoxide Dismutase Induced by Dopamine in Cultured Astrocytes, Neurochemical Research, 2013, 38, 1, 32

    CrossRef

  4. 4
    Elzbieta Janda, Ciro Isidoro, Cristina Carresi, Vincenzo Mollace, Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress, Molecular Neurobiology, 2012, 46, 3, 639

    CrossRef

  5. 5
    Susana Arellano-Ruiz, Camilo Rios, Hermelinda Salgado-Ceballos, Marisela Méndez-Armenta, Leonardo del Valle-Mondragón, Concepción Nava-Ruiz, Marina Altagracia-Martínez, Araceli Díaz-Ruiz, Metallothionein-II improves motor function recovery and increases spared tissue after spinal cord injury in rats, Neuroscience Letters, 2012, 514, 1, 102

    CrossRef

  6. 6
    Cecília R. A. Santos, Ana Martinho, Telma Quintela, Isabel Gonçalves, Neuroprotective and neuroregenerative properties of metallothioneins, IUBMB Life, 2012, 64, 2
    Direct Link:
  7. 7
    Eun-Joo Shin, Chu Xuan Duong, Xuan-Khanh Thi Nguyen, Zhengyi Li, Guoying Bing, Jae-Hyung Bach, Dae Hun Park, Keiichi Nakayama, Syed F. Ali, Anumantha G. Kanthasamy, Jean Lud Cadet, Toshitaka Nabeshima, Hyoung-Chun Kim, Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ, Behavioural Brain Research, 2012, 232, 1, 98

    CrossRef

  8. 8
    Aracely Garcia-Garcia, Laura Zavala-Flores, Humberto Rodriguez-Rocha, Rodrigo Franco, Thiol-Redox Signaling, Dopaminergic Cell Death, and Parkinson's Disease, Antioxidants & Redox Signaling, 2012, 17, 12, 1764

    CrossRef

  9. 9
    ME Choudhury, K Sugimoto, M Kubo, H Iwaki, T Tsujii, WT Kyaw, N Nishikawa, M Nagai, J Tanaka, M Nomoto, Zonisamide up-regulated the mRNAs encoding astrocytic anti-oxidative and neurotrophic factors, European Journal of Pharmacology, 2012, 689, 1-3, 72

    CrossRef

  10. 10
    Mohammed Emamussalehin Choudhury, Kana Sugimoto, Madoka Kubo, Masahiro Nagai, Masahiro Nomoto, Hisaaki Takahashi, Hajime Yano, Junya Tanaka, A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats, Brain and Behavior, 2011, 1, 1
    Direct Link:
  11. 11
    Daisuke Ogawa, Masato Asanuma, Ikuko Miyazaki, Hiromi Tachibana, Jun Wada, Norio Sogawa, Takeshi Sugaya, Shinji Kitamura, Yohei Maeshima, Kenichi Shikata, Hirofumi Makino, High Glucose Increases Metallothionein Expression in Renal Proximal Tubular Epithelial Cells, Experimental Diabetes Research, 2011, 2011, 1

    CrossRef

  12. 12
    Janusz Lipski, Robert Nistico, Nicola Berretta, Ezia Guatteo, Giorgio Bernardi, Nicola B. Mercuri, l-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?, Progress in Neurobiology, 2011, 94, 4, 389

    CrossRef

View Full Article with Supporting Information (HTML) Get PDF (6624K)