Microglia/macrophages promote glioma progression

Authors

  • Haiyan Zhai,

    1. Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York
    2. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York
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  • Frank L. Heppner,

    1. Department of Neuropathology, Charité–Universitätsmedizin Berlin, Germany
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  • Stella E. Tsirka

    Corresponding author
    1. Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York
    2. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York
    • Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794-8651, USA
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Abstract

Gliomas are highly aggressive and accompanied by numerous microglia/macrophages (MG/MP) in and about the tumor. Little is known about what MG/MP do in this setting, or whether modulating MG/MP activation might affect glioma progression. Here, we used a glioma-microglia in culture system to establish the effects the tumor and microglia have on each other. We assessed glioma progression in vivo after MG/MP ablation or in the setting of exaggerated MG/MP activation. We show that glioma cells activate microglia but inhibit their phagocytic activities. Local ablation of MG/MP in vivo decreased tumor size and improved survival curves. Conversely, pharmacological activation of MG/MP increased glioma size through stimulating tumor proliferation and inhibiting apoptosis. In agreement with recent reports, expression of the chemokine CCL21 is enhanced after MG/MP activation and correlates with tumor growth. Taken together, our findings demonstrate that inhibition of MG/MP activation may constitute a new and effective contribution towards suppressing glioma proliferation. © 2010 Wiley-Liss, Inc.

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