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In vitro modeling of central nervous system myelination and remyelination

Authors

  • Andrew A. Jarjour,

    1. MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, Little France Crescent, Edinburgh, United Kingdom
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  • Hui Zhang,

    1. MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, Little France Crescent, Edinburgh, United Kingdom
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  • Nina Bauer,

    1. MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, Little France Crescent, Edinburgh, United Kingdom
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  • Charles ffrench-Constant,

    1. MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, Little France Crescent, Edinburgh, United Kingdom
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  • Anna Williams

    Corresponding author
    1. MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, Little France Crescent, Edinburgh, United Kingdom
    • MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, 47, Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
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Abstract

This review aims to summarize the current techniques to study myelination and remyelination in culture systems. We attempt to put these into historical context, and to identify the strengths and weaknesses of each approach, which vary depending on the experimental question to be tested. We discuss the difficulty and importance of quantification of myelination and in particular remyelination. Finally, we provide our predictions of how these techniques will and should develop in the future. © 2011 Wiley Periodicals, Inc.

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