Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis
Article first published online: 30 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Volume 60, Issue 1, pages 43–52, January 2012
How to Cite
Van Der Putten, C., Kuipers, H. F., Zuiderwijk-Sick, E. A., Van Straalen, L., Kondova, I., Van Den Elsen, P. J. and Bajramovic, J. J. (2012), Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis. Glia, 60: 43–52. doi: 10.1002/glia.21245
- Issue published online: 14 NOV 2011
- Article first published online: 30 SEP 2011
- Manuscript Accepted: 29 AUG 2011
- Manuscript Received: 10 MAY 2011
Additional Supporting Information may be found in the online version of this article.
|GLIA_21245_sm_SuppFig1.tiff||3042K||Supporting Information Figure 1. Scheme of the mevalonate pathway. Zaragozic Acid A (Zara) ia a potent inhibitor of squalene synthase which results in inhibiting cholesterol biosynthesis but not isoprenylation. Specific inhibitors of the isoprenylation pathway included GGTI-2133: inhibitor of geranylgeranyltransferase, and FTI-277: inhibitor of farnesyltransferase.|
|GLIA_21245_sm_SuppTab1.doc||56K||Supporting Information Table 1. Donor specifications|
|GLIA_21245_sm_SuppTab2A.doc||54K||Supporting Information Table 2A. TLR2-induced cytokine/chemokine and growth factor levels in microglia from different donors.|
|GLIA_21245_sm_SuppTab2B.doc||39K||Supporting Information Table 2B. TLR2, 3, 4 and 8-induced cytokine/chemokine and growth factor levels in microglia from donor N90.|
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