H. Zhu, L. Zhao, and E. Wang contributed equally to this work.
The QKI-PLP pathway controls SIRT2 abundance in CNS myelin
Article first published online: 21 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Volume 60, Issue 1, pages 69–82, January 2012
How to Cite
Zhu, H., Zhao, L., Wang, E., Dimova, N., Liu, G., Feng, Y. and Cambi, F. (2012), The QKI-PLP pathway controls SIRT2 abundance in CNS myelin. Glia, 60: 69–82. doi: 10.1002/glia.21248
- Issue published online: 14 NOV 2011
- Article first published online: 21 SEP 2011
- Manuscript Accepted: 30 AUG 2011
- Manuscript Received: 7 APR 2011
- NIH/NINDS. Grant Number: RO1NS053905
- European Leukodystrophy Association. Grant Number: 2008-013I1
- NIH/NINDS. Grant Number: R01NS056097
- NMSS. Grant Number: RG4010-A-2
Additional Supporting Information may be found in the online version of this article.
|GLIA_21248_sm_SuppFig1.tif||108K||Supporting Information Figure 1. SIRT2 message levels are not affected in the q/q mutant brain. SIRT2 message levels were quantitated by Real Time qRT-PCR in RNA extracted from q/w and q/q brainstem at P40 (n=3). Bar graph is the mean±SD of data obtained from three independent determinations in three separate mice. There are not differences between q/w and q/q.|
|GLIA_21248_sm_SuppFig2.tif||1762K||Supporting Information Figure 2. SIRT2 is present in the cell body, processes and myelin sheaths of the PLP-ISEdel OL in vitro. Representative immunocytochemical staining of a PLP-ISEdel OL differentiated for 72 hrs with SIRT2 (red) and the oligodendrocyte-specific surface marker recognized by the O4 antibody (green). The merged image shows that SIRT2 is localized in the cell body, processes and in the cytoplasm of the myelin sheath (arrows) (n=3).|
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