Aquaporin-4 and epilepsy
Article first published online: 29 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: Astrocytes and Epilepsy
Volume 60, Issue 8, pages 1203–1214, August 2012
How to Cite
Binder, D. K., Nagelhus, E. A. and Ottersen, O. P. (2012), Aquaporin-4 and epilepsy. Glia, 60: 1203–1214. doi: 10.1002/glia.22317
- Issue published online: 12 JUN 2012
- Article first published online: 29 FEB 2012
- Manuscript Accepted: 9 FEB 2012
- Manuscript Received: 2 NOV 2011
- Letten Foundation and the Research Council of Norway
- Mentored Clinical Scientist Research Career Development Award. Grant Number: K08 NS059674
- American Epilepsy Society/Milken Family Foundation Early Career Physician-Scientist Award
- Epilepsy Foundation of America Research Grant
Recent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors, and transporters have all been associated with the epileptic state. This review focuses on the potential roles of the glial water channel aquaporin-4 (AQP4) in modulation of brain excitability and in epilepsy. We will review studies of mice lacking AQP4 (Aqp4−/− mice) or α-syntrophin (an AQP4 anchoring protein) and discuss the available human studies demonstrating alterations of AQP4 in human epilepsy tissue specimens. We will conclude with new studies of AQP4 regulation and discuss the potential role of AQP4 in the development of epilepsy (epileptogenesis). While many questions remain unanswered, the available data indicate that AQP4 and its molecular partners may represent important new therapeutic targets. © 2012 Wiley Periodicals, Inc.