Cdc42 regulates schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling
Article first published online: 6 SEP 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 61, Issue 11, pages 1906–1921, November 2013
How to Cite
Guo, L., Moon, C., Zheng, Y. and Ratner, N. (2013), Cdc42 regulates schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia, 61: 1906–1921. doi: 10.1002/glia.22567
- Issue published online: 20 SEP 2013
- Article first published online: 6 SEP 2013
- Manuscript Accepted: 2 AUG 2013
- Manuscript Revised: 2 JUL 2013
- Manuscript Received: 18 APR 2013
- NIH . Grant Number: R01CA118032
Additional Supporting Information may be found in the online version of this article.
|glia22567-sup-0001-suppinfo01.doc||159K||Supplemental Figure 1. Increased proliferation in adult Cdc42-CKO nerves is independent of NF2/merlin. (A) Brdu incorporation in control and Cdc42-CKO nerves at P30 was visualized by Brdu staining (Red). Nuclei were visualized by DAPI (blue). (B) There was a significant increase in percentage of Brdu positive cells in Cdc42-CKO nerves. (C) Brdu staining in control, Cdc42-CKO, NF2-del and Cdc42-CKO;NF2-del nerves at P30 were shown. (D) There was no significant change of Brdu-positive cells percentage in Cdc42-CKO;NF2-del nerves compared with Cdc42-CKO nerves. (E) Total nuclei numbers in P30 control, Cdc42-CKO, NF2-del and Cdc42-CKO;NF2-del nerve cross sections. (F) Ki67 staining in P0 control and Cdc42-CKO nerve longitudinal sections. (G) Percentage of Ki67-positive cells in control and Cdc42-CKO nerves at P0. n =10 sections from at least 3 individual animals per genotype. *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA followed by Tukey test. Error bars indicate } SEM. Bars: (C) 50 μm.|
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