Glial influence on the blood brain barrier

Authors

  • Jorge Ivan Alvarez,

    Corresponding author
    1. Neuroimmunology unit, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada
    • Address correspondence to Jorge Ivan Alvarez, Neuroimmunology Research Laboratory (Y-3608), CRCHUM-Notre-Dame Hospital, 2099 Alexandre de Seve, Montréal, Quebec, Canada H2L 2W5. E-mail: jorge.alvarez@umontreal.ca

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  • Takahiro Katayama,

    1. Neuroimmunology unit, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada
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  • Alexandre Prat

    1. Neuroimmunology unit, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada
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Abstract

The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype. GLIA 2013;61:1939–1958

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