Diazepam binding inhibitor fragment 33–50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells
Article first published online: 12 OCT 2004
Copyright © 1994 Wiley-Liss, Inc.
Volume 10, Issue 2, pages 132–141, February 1994
How to Cite
Vidnyánszky, Z., Görcs, T. J. and Hámori, J. (1994), Diazepam binding inhibitor fragment 33–50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells. Glia, 10: 132–141. doi: 10.1002/glia.440100207
- Issue published online: 12 OCT 2004
- Article first published online: 12 OCT 2004
- Manuscript Accepted: 19 JUL 1993
- Manuscript Received: 3 MAY 1993
- Bergmann glia;
The distribution of octadecaneuropeptide (ODN)-like immunoreactivity (LI) and its relationship to γ-aminobutyric acid (GABA)-LI were investigated in the cerebellar cortex of adult rats with electron microscopy. At the electron microscopic level, ODN-LI was found exclusively in glial cells. In addition to Bergmann glia and its processes, cerebellar astrocytes were also labelled, encapsulating unlabelled neuronal elements of the cerebellum. These ODN-LI glial processes were observed in close apposition to synaptic junctions, but immunoreactivity could not be found in the synaptic cleft or in association with neuronal membranes. Since GABA-LI is always associated with neuronal elements, the colocalization of GABA- and ODN-LI could not be confirmed in the cerebellar cortex. Our results do not support the assumption that ODN is a neuron-specific processing product of diazepam binding inhibitor. © 1994 Wiley-Liss, Inc.