Cover image for Vol. 62 Issue 5

May 2014

Volume 62, Issue 5

Pages 667–839

  1. Original Research Articles

    1. Top of page
    2. Original Research Articles
    1. The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4 (pages 667–679)

      Maria Pannell, Frank Szulzewsky, Vitali Matyash, Susanne A. Wolf and Helmut Kettenmann

      Version of Record online: 7 FEB 2014 | DOI: 10.1002/glia.22633

      Main Points:

      • We found that subpopulations of acutely isolated or cultured microglia express distinct neurohormone and neurotransmitter receptors. We observed that these subpopulations change in cultured microglial cells when activated indicating that microglia comprise a highly heterogeneous population of cells with respect to their chemosensitivity.
    2. Genetic inactivation of PERK signaling in mouse oligodendrocytes: Normal developmental myelination with increased susceptibility to inflammatory demyelination (pages 680–691)

      Yassir Hussien, Douglas R. Cavener and Brian Popko

      Version of Record online: 31 JAN 2014 | DOI: 10.1002/glia.22634

      Main Points:

      • This report provide evidence that although the integrated stress response is expendable during normal oligodendrocyte development and CNS myelination, this protective pathway defends oligodendrocytes and myelin against inflammatory demyelination.
    3. Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures (pages 692–708)

      Charles L. Howe, Tatiana Kaptzan, Setty M. Magaña, Jennifer R. Ayers-Ringler, Reghann G. LaFrance-Corey and Claudia F. Lucchinetti

      Version of Record online: 3 FEB 2014 | DOI: 10.1002/glia.22635

      Main Points:

      • The disease-defining immunoglobulin associated with neuromyelitis optica stimulates a robust reactive and inflammatory response in primary rat astrocyte cultures. This response may explain the recruitment of granulocytes observed in patient lesions.
    4. DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation (pages 709–724)

      Shoko Shimizu, Yoshihisa Koyama, Tsuyoshi Hattori, Taro Tachibana, Tomohiko Yoshimi, Hisayo Emoto, Yuji Matsumoto, Shingo Miyata, Taiichi Katayama, Akira Ito and Masaya Tohyama

      Version of Record online: 30 JAN 2014 | DOI: 10.1002/glia.22636

      Main Points:

      • We report that DBZ (DISC1 Binding Zinc-finger protein), a central nervous system (CNS)-specific member of the DISC1 interactome, is expressed in oligodendrocytes and positively regulates the oligodendrocyte differentiation.
    5. The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes (pages 725–735)

      Gaelle Elain, Karine Jeanneau, Aleksandra Rutkowska, Anis K. Mir and Kumlesh K. Dev

      Version of Record online: 14 FEB 2014 | DOI: 10.1002/glia.22637

      Main Points:

      • Human astrocytes express IL17RA and IL17RC and combined treatment with IL17A/TNFα increases levels of IL6 via NFκB signalling
      • In human astrocytes, IL17A/ TNFα induces mRNA expression of IL6, IL8 and the Th17 cytokines CXCL1, CXCL2 and CCL20, with little effect on Th1 cytokines CXCL9, CXCL10 and CXCL11.
      • Importantly, treatment with the IL17A selective antibody secukinumab (AIN457) attenuates IL17A/TNFα increase in levels of IL6
    6. Nonuniform molecular features of myelinating Schwann cells in models for CMT1: Distinct disease patterns are associated with NCAM and c-Jun upregulation (pages 736–750)

      Dennis Klein, Janos Groh, Jennifer Wettmarshausen and Rudolf Martini

      Version of Record online: 13 FEB 2014 | DOI: 10.1002/glia.22638

      Main Points:

      • Myelinating Schwann cells in different models of CMT1 show a non-uniform molecular profile, with increased NCAM expression in SLI being a putative marker for early Schwann cell abnormality, and c-Jun upregulation for pre-demyelinating axonal perturbation. By contrast, supernumerary Schwann cells and myelin deficient Schwann cells are uniformly “labeled” in all mutants.
    7. Effects of dextromethorphan on glial cell function: Proliferation, maturation, and protection from cytotoxic molecules (pages 751–762)

      Robert P. Lisak, Liljana Nedelkoska and Joyce A. Benjamins

      Version of Record online: 13 FEB 2014 | DOI: 10.1002/glia.22639

      Main Points:

      • Dextromethorphan stimulates proliferation of oligodendroglial progenitors in culture.
      • Treatment of oligodendroglial progenitors with dextromethorphan increases the % of progenitors relative to differentiated oligodendroglia.
      • Dextromethorphan protects both oligodendroglia and their progenitors against excitotoxic and inflammatory insults.
    8. Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons (pages 763–777)

      Joelle R. Nadeau, Tracy D. Wilson-Gerwing and Valerie M.K. Verge

      Version of Record online: 24 FEB 2014 | DOI: 10.1002/glia.22640

      Main Points:

      • Sensory neuron p75 neurotrophin receptor (p75NTR) signaling maintains perineuronal satellite glial cell (SGC) homeostatic phenotype.
      • Reduced p75NTR expression in uninjured sensory neuron induces robust SGC phenotype changes consistent with nerve injury.
    9. GSK3β regulates oligodendrogenesis in the dorsal microdomain of the subventricular zone via Wnt-β-catenin signaling (pages 778–789)

      Kasum Azim, Andrea Rivera, Olivier Raineteau and Arthur M. Butt

      Version of Record online: 14 FEB 2014 | DOI: 10.1002/glia.22641

      Main Points:

      • Infusion of the GSK3β inhibitor ARA-014418 into the lateral ventricle of postnatal mice identifies a key role for canonical Wnt/β-catenin signalling in regulating oligodendrogenesis from neural stem cells of the subventricular zone.
    10. Age-related changes in astrocytic and ependymal cells of the subventricular zone (pages 790–803)

      Vivian Capilla-Gonzalez, Arantxa Cebrian-Silla, Hugo Guerrero-Cazares, Jose Manuel Garcia-Verdugo and Alfredo Quiñones-Hinojosa

      Version of Record online: 14 FEB 2014 | DOI: 10.1002/glia.22642

      Main Points:

      • (i) We investigate the proliferative activity of the NSCs during aging, showing that they divide less frequently than in the young mice; (ii) We explore the cell differentiation process of the NSCs, providing new evidence that they do not generate new ependymal cells during aging; (iii) Interestingly, we found that both astrocytes and ependymal cells acquire features of reactive cells in the aged SVZ. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies to fight neurological disorders linked to senescence.
    11. You have full text access to this OnlineOpen article
      Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice (pages 804–817)

      Xing-Mei Zhang, Harald Lund, Sohel Mia, Roham Parsa and Robert A. Harris

      Version of Record online: 14 FEB 2014 | DOI: 10.1002/glia.22643

      Main Points:

      • Adoptively transferred M2 adult microglia injected intra-nasally into mice reduced chronic MOG-EAE clinical symptoms. M2 microglia induced regulatory T cells, suppressed T cell proliferation and down-modulated M1-associated receptor expression
    12. Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member (pages 818–828)

      Ian D. Cooley, Vinita S. Chauhan, Miguel A. Donneyz and Ian Marriott

      Version of Record online: 14 FEB 2014 | DOI: 10.1002/glia.22644

      Main Points:

      • Murine and human astrocytes produce the IL-10 family member IL-19 following bacterial challenge. Astrocytes functionally express the cognate receptor for this cytokine and IL-19 limits inflammatory responses initiated by bacteria or TLR ligands.
    13. Stage-specific requirement for cyclin D1 in glial progenitor cells of the cerebral cortex (pages 829–839)

      Lionel Nobs, Constanze Baranek, Sigrun Nestel, Akos Kulik, Josef Kapfhammer, Cordula Nitsch and Suzana Atanasoski

      Version of Record online: 19 FEB 2014 | DOI: 10.1002/glia.22646

      Main Points:

      • The molecular control of cell division in glial cells is cell and stage-specific.
      • Proliferation of oligodendrocyte progenitor cells becomes gradually dependent on cyclin D1.
      • Numbers of myelinating oligodendrocytes are reduced in the absence of cyclin D1.