MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic
Article first published online: 26 OCT 2005
Copyright © 2005 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 20, Issue 11, pages 1060–1066, November 2005
How to Cite
van der Flier, W. M., van der Vlies, A. E., Weverling-Rijnsburger, A. W. E., de Boer, N. L., Admiraal-Behloul, F., Bollen, E. L. E. M., Westendorp, R. G. J., van Buchem, M. A. and Middelkoop, H. A. M. (2005), MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic. Int. J. Geriat. Psychiatry, 20: 1060–1066. doi: 10.1002/gps.1392
- Issue published online: 26 OCT 2005
- Article first published online: 26 OCT 2005
- Manuscript Accepted: 1 JUN 2005
- Manuscript Received: 14 FEB 2005
- Internationale Stichting Alzheimer Onderzoek (ISAO)
- magnetic resonance imaging;
- white matter hyperintensities;
To investigate whether MRI-based volumes of whole brain, medial temporal lobe and white matter hyperintensities (WMH) predict progression of cognitive decline in a sample of nondemented elderly.
Thirty-seven nondemented elderly attending a memory clinic and 28 elderly controls participated in this follow-up study. The average follow-up period was 1.8 years. Cognitive function was measured at baseline and follow-up with the Cambridge Cognitive Examination (CAMCOG). Baseline Magnetic Resonance Imaging (MRI) provided quantitative measures of whole brain, medial temporal lobe and WMH. Linear mixed models controlled for age and sex were used to assess the independent associations between MRI measures, baseline cognition, and annual decline in cognition.
Medial temporal lobe volume was independently associated with baseline CAMCOG score (p < 0.01), whereas whole brain volume (p < 0.01) and WMH (p < 0.05) were associated with annual decline in CAMCOG score.
These data suggest that regional damage to the medial temporal lobes underlies initial mild cognitive impairment, whereas more global brain changes, such as whole brain atrophy and WMH, contribute to further progression of cognitive decline. Copyright © 2005 John Wiley & Sons, Ltd.