Differences in heart rate variability between depressed and non-depressed elderly
Article first published online: 16 JAN 2006
Copyright © 2006 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 21, Issue 2, pages 147–150, February 2006
How to Cite
van der Kooy, K. G., van Hout, H. P. J., van Marwijk, H. W. J., de Haan, M., Stehouwer, C. D. A. and Beekman, A. T. F. (2006), Differences in heart rate variability between depressed and non-depressed elderly. Int. J. Geriat. Psychiatry, 21: 147–150. doi: 10.1002/gps.1439
- Issue published online: 27 JAN 2006
- Article first published online: 16 JAN 2006
- Manuscript Accepted: 21 JUL 2005
- Manuscript Received: 11 APR 2005
- The Netherlands Heart Foundation, The Hague, The Netherlands. Grant Number: 2000 B 038
- major depression;
- heart rate variability;
- autonomic nervous system;
- primary care
To determine whether older primary care patients with a Major Depressive Disorder (MDD) have lower heart rate variability (HRV) compared to non-depressed patients. HRV is a measure of cardiac autonomic functioning.
A cross-sectional comparison of 136 elderly persons with MDD and 136 non-depressed controls (matched for age and gender) recruited in family practices in the Netherlands. Depression was determined according to the DSM–IV criteria using the PRIME–MD. HRV was measured with an electrocardiogram (ECG) during a 5-minute supine rest.
Multivariate analyses showed statistically significant decrease in HRV in MDD patients compared with controls.
Older primary care patients with MDD have a reduced HRV. This may explain why depression is a risk factor for cardiovascular disease and mortality. Copyright © 2006 John Wiley & Sons, Ltd.