The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
Article first published online: 15 SEP 2006
Copyright © 2006 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 21, Issue 11, pages 1078–1085, November 2006
How to Cite
Mioshi, E., Dawson, K., Mitchell, J., Arnold, R. and Hodges, J. R. (2006), The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int. J. Geriat. Psychiatry, 21: 1078–1085. doi: 10.1002/gps.1610
- Issue published online: 23 OCT 2006
- Article first published online: 15 SEP 2006
- Manuscript Accepted: 12 APR 2006
- Manuscript Received: 15 DEC 2005
- Medical Research Council Programme
- Addenbrooke's Cognitive Examination;
- Alzheimer's disease;
- mild cognitive impairment
There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE).
We aimed to validate an improved revision (the ACE-R) which incorporates five sub-domain scores (orientation/attention, memory, verbal fluency, language and visuo-spatial).
Standard tests for evaluating dementia screening tests were applied. A total of 241 subjects participated in this study (Alzheimer's disease = 67, frontotemporal dementia = 55, dementia of Lewy Bodies = 20; mild cognitive impairment–MCI = 36; controls = 63).
Reliability of the ACE-R was very good (alpha coefficient = 0.8). Correlation with the Clinical Dementia Scale was significant (r = −0.321, p < 0.001). Two cut-offs were defined (88: sensitivity = 0.94, specificity = 0.89; 82: sensitivity = 0.84, specificity = 1.0). Likelihood ratios of dementia were generated for scores between 88 and 82: at a cut-off of 82 the likelihood of dementia is 100:1. A comparison of individual age and education matched groups of MCI, AD and controls placed the MCI group performance between controls and AD and revealed MCI patients to be impaired in areas other than memory (attention/orientation, verbal fluency and language).
The ACE-R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction. Copyright © 2006 John Wiley & Sons, Ltd.