Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease
Article first published online: 5 SEP 2006
Copyright © 2006 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 21, Issue 12, pages 1132–1138, December 2006
How to Cite
Vogel, A., Mortensen, E. L., Hasselbalch, S. G., Andersen, B. B. and Waldemar, G. (2006), Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease. Int. J. Geriat. Psychiatry, 21: 1132–1138. doi: 10.1002/gps.1619
- Issue published online: 23 NOV 2006
- Article first published online: 5 SEP 2006
- Manuscript Accepted: 25 APR 2006
- Manuscript Received: 14 MAR 2006
- Danish 1991 Pharmacy Foundation
- Danish Alzheimer Research Foundation
- Danish Health Insurance Fund
- quality of life;
- Alzheimer's disease;
- awareness of deficits;
- neuropsychiatric symptoms
The study investigated if patient and informant reported Quality of Life (QoL) differed in early Alzheimer's disease (AD). In addition, we examined whether anosognosia had an impact on the agreement between patient and informant ratings of QoL and whether anosognosia, dementia severity, depression and behavioural symptoms were significantly correlated to QoL in early AD.
From a prospective research program including newly referred patients (age >60 years and MMSE ≥ 20), 48 patients with very early AD were included. QoL was assessed using the QoL-AD and EQ-5D scales. Anosognosia was rated on a categorical scale by an examiner. MMSE, Geriatric Depression Scale, Danish Adult Reading Test and Frontal Behavioural Inventory were also administered.
On most QoL measures patients rated their QoL higher than their informants. Anosognosia was not associated with QoL but significantly with an inverse impact on the agreement between patient and informant ratings of QoL. Self-reported QoL was significantly correlated to depression but not to age, dementia severity, behavioural symptoms or memory impairment. Informant ratings of QoL were significantly correlated to behavioural symptoms and informant ratings on the EQ-5D Visual Analogue Scale were significantly correlated to patient reported depression.
Patients with early AD generally reported higher QoL than their informants. This disagreement was associated with the presence of anosognosia. Self-reported QoL did not correlate with the MMSE score. Behavioural changes and depressive symptoms may be associated with low QoL. Copyright © 2006 John Wiley & Sons, Ltd.