No conflict of interest was declared.
Cognitive functioning in elderly patients with early onset bipolar disorder†
Article first published online: 30 JAN 2007
Copyright © 2007 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 22, Issue 9, pages 856–861, September 2007
How to Cite
Schouws, S. N. T. M., Zoeteman, J. B., Comijs, H. C., Stek, M. L. and Beekman, A. T. F. (2007), Cognitive functioning in elderly patients with early onset bipolar disorder. Int. J. Geriat. Psychiatry, 22: 856–861. doi: 10.1002/gps.1751
- Issue published online: 23 AUG 2007
- Article first published online: 30 JAN 2007
- Manuscript Accepted: 21 NOV 2006
- Manuscript Received: 11 AUG 2006
- bipolar disorder;
Very little is known about the long term cognitive sequelae of bipolar disorder.
To investigate neuropsychological functioning in older euthymic persons with early onset bipolar disorder.
Fifteen older patients (age >60) with an early onset (<50 years) bipolar-I disorder in a euthymic mood were tested using a comprehensive neuropsychological test battery. Neuropsychological functioning was compared with that of a sex, age and education-matched group of 15 comparison subjects without mood disorders or memory complaints.
Bipolar subjects scored lower than comparison subjects on selective attention, verbal memory, verbal fluency and mental effort tests.
The findings suggest that euthymic bipolar patients are impaired across a range of cognitive domains. This could represent a trait-like cognitive disability related to the disease, as the impairments are comparable with those found in younger bipolar patients. Copyright © 2007 John Wiley & Sons, Ltd.