Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
Article first published online: 4 APR 2007
Copyright © 2007 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 22, Issue 5, pages 485–491, May 2007
How to Cite
Winblad, B., Kawata, A. K., Beusterien, K. M., Thomas, S. K., Wimo, A., Lane, R., Fillit, H. and Blesa, R. (2007), Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease. Int. J. Geriat. Psychiatry, 22: 485–491. doi: 10.1002/gps.1806
- Issue published online: 30 APR 2007
- Article first published online: 4 APR 2007
- Manuscript Accepted: 26 FEB 2007
- Manuscript Received: 8 DEC 2006
- Alzheimer's disease (AD);
- randomized clinical trial (RCT);
- treatment preference
Family caregivers comprise a critical component in the care of Alzheimer's disease (AD) patients. Among their many tasks, caregivers are responsible for administering and managing medications. Effective interventions incorporate the needs of both the AD patient and the caregiver, and understanding treatment preferences may maximize intervention effectiveness. Transdermal patches may offer advantages over conventional oral formulations.
A 24-week randomized controlled trial compared the rivastigmine patch to the rivastigmine capsule and placebo in patients with probable AD. At baseline and Weeks 8 and 24, the AD Caregiver Preference Questionnaire (ADCPQ) was used to evaluate caregiver expectations, preferences and satisfaction with treatment. Double-dummy treatment blinding ensured that caregiver preference for the patch or capsule was not confounded by perceptions of efficacy or tolerability. Reasons for preference were also elicited. The analytic sample included caregivers who completed the ADCPQ at Weeks 8 and/or 24.
One thousand and fifty-nine caregivers completed the ADCPQ. More than 70% of caregivers preferred the rivastigmine patch to the capsule. The patch was significantly preferred to the capsule with respect to ease of following the schedule and ease of use. Caregivers indicated greater satisfaction overall, greater satisfaction with administration, and less interference with daily life with the patch versus the capsule (all p ≤ 0.01).
Caregivers of AD patients preferred the patch to the capsule for drug delivery. Preference for the rivastigmine patch could potentially lead to improved compliance and improved clinical benefits. Copyright © 2007 John Wiley & Sons, Ltd.