Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies
Article first published online: 20 NOV 2007
Copyright © 2007 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 23, Issue 6, pages 598–603, June 2008
How to Cite
Diederich, N. J., Leurgans, S., Fan, W., Chmura, T. A. and Goetz, C. G. (2008), Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies. Int. J. Geriat. Psychiatry, 23: 598–603. doi: 10.1002/gps.1945
- Issue published online: 28 MAY 2008
- Article first published online: 20 NOV 2007
- Manuscript Accepted: 2 OCT 2007
- Manuscript Received: 3 JUL 2007
- progressive supranuclear palsy (PSP);
- corticobasal degeneration (CBD);
- visual hallucinations;
- REM sleep behavior disorder (RBD);
In Parkinsonism, visual hallucinations (VH) and REM sleep behavior disorder (RBD) have been thought to indicate underlying synucleinopathy.
We tested the validity of this hypothesis by searching for VH and RBD symptoms in Parkinsonism related to tauopathies.
Patients with progressive supranuclear palsy or corticobasal degeneration were identified via a clinical data bank.
Of 53 patients who expressed study interest by telephone, 44 returned questionnaires. VH occurred in 16% of patients. Similarly, acting out of dreams occurred in 16% of patients. Neither VH nor RBD symptoms were linked to disease duration or dopaminergic medication and there was no mutual association.
VH and RBD symptoms also occur in Parkinsonism related to tauopathies, thus refuting the initial hypothesis. Copyright © 2007 John Wiley & Sons, Ltd.