Research Article

You have free access to this content

Anterior cingulate cortical volumes and treatment remission of geriatric depression

  1. Faith M. Gunning1,*,
  2. Janice Cheng1,
  3. Christopher F. Murphy1,
  4. Dora Kanellopoulos1,
  5. Jessica Acuna1,
  6. Matthew J. Hoptman2,3,
  7. Sibel Klimstra1,
  8. Shizuko Morimoto1,
  9. James Weinberg1,
  10. George S. Alexopoulos1

Article first published online: 23 JUN 2009

DOI: 10.1002/gps.2290

Issue

International Journal of Geriatric Psychiatry

International Journal of Geriatric Psychiatry

Special Issue: Neuroimaging in Geriatric Psychiatry

Volume 24, Issue 8, pages 829–836, August 2009

Additional Information

How to Cite

Gunning, F. M., Cheng, J., Murphy, C. F., Kanellopoulos, D., Acuna, J., Hoptman, M. J., Klimstra, S., Morimoto, S., Weinberg, J. and Alexopoulos, G. S. (2009), Anterior cingulate cortical volumes and treatment remission of geriatric depression. Int. J. Geriat. Psychiatry, 24: 829–836. doi: 10.1002/gps.2290

Author Information

  1. 1

    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA

  2. 2

    Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA

  3. 3

    Department of Psychiatry, New York University School of Medicine, New York, NY, USA

*21 Bloomingdale Road; White Plains, NY 10605, USA.

Publication History

  1. Issue published online: 10 JUL 2009
  2. Article first published online: 23 JUN 2009
  3. Manuscript Accepted: 3 MAR 2009
  4. Manuscript Received: 21 NOV 2008

Funded by

  • National Institute of Mental Health. Grant Numbers: P30 MH68638 (GSA), R01 MH65653 (GSA), K23 MH074818 (FGD)
  • Sanchez Foundation
  • TRU Foundation
  • Forest Pharmaceuticals

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (138K)

REFERENCES

  • Aizenstein HJ, Butters MA, Wu M, et al. 2009. Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena. Am J Geriatr Psychiatry 17: 30–42.
  • Alexopoulos GS, Gunning-Dixon FM, Latoussakis V, et al. 2008a. Anterior cingulate dysfunction in geriatric depression. Int J Geriatr Psychiatry 23: 347–355.
    Direct Link:
  • Alexopoulos GS, Kiosses DN, Choi SJ, et al. 2002. Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry 159: 1929–1932.
  • Alexopoulos GS, Murphy CF, Gunning-Dixon FM, et al. 2008b. Microstructural white matter abnormalities and remission of geriatric depression. Am J Psychiatry 165: 238–244.
  • Ballmaier M, Toga AW, Blanton RE, et al. 2004. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry 161: 99–108.
  • Botvinick MM, Cohen JD, Carter CS. 2004. Conflict monitoring and anterior cingulate cortex: an update. Trends Cogn Sci 8: 539–546.
  • Bush G, Luu P, Posner MI. 2000. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4: 215–222.
  • Carter CS, Braver TS, Barch DM, et al. 1998. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 280: 747–749.
  • Carter CS, van Veen V. 2007. Anterior cingulate cortex and conflict detection: an update of theory and data. Cogn Affect Behav Neurosci 7: 367–379.
  • Chen CH, Ridler K, Suckling J, et al. 2007. Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biol Psychiatry 62: 407–414.
  • Davidson RJ, Irwin W, Anderle MJ, et al. 2003. The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry 160: 64–75.
  • de Asis JM, Stern E, Alexopoulos GS, et al. 2001. Hippocampal and anterior cingulate activation deficits in patients with geriatric depression. Am J Psychiatry 158: 1321–1323.
  • Devinsky O, Morrell MJ, Vogt BA. 1995. Contributions of anterior cingulate cortex to behaviour. Brain 118 (Pt 1): 279–306.
  • Dew MA, Whyte EM, Lenze EJ, et al. 2007. Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy. Am J Psychiatry 164: 892–899.
  • Drevets WC. 1998. Functional neuroimaging studies of depression: the anatomy of melancholia. Annu Rev Med 49: 341–361.
  • Drevets WC, Bogers W, Raichle ME. 2002. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 12: 527–544.
  • Elderkin-Thompson V, Hellemann G, Pham D, et al. 2009. Prefrontal brain morphology and executive function in healthy and depressed elderly. Int J Geriatr Psychiatry 24: 459–468.
    Direct Link:
  • Etkin A, Egner T, Peraza DM, et al. 2006. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 51: 871–882.
  • Folstein MF, Folstein SE, McHugh PR. 1975. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198.
  • Holthoff VA, Beuthien-Baumann B, Zundorf G, et al. 2004. Changes in brain metabolism associated with remission in unipolar major depression. Acta Psychiatr Scand 110: 184–194.
    Direct Link:
  • Kennedy SH, Evans KR, Kruger S, et al. 2001. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. Am J Psychiatry 158: 899–905.
  • Kennedy SH, Konarski JZ, Segal ZV, et al. 2007. Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trial. Am J Psychiatry 164: 778–788.
  • Langenecker SA, Kennedy SE, Guidotti LM, et al. 2007. Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder. Biol Psychiatry 62: 1272–1280.
  • Lavretsky H, Ballmaier M, Pham D, et al. 2007. Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Am J Geriatr Psychiatry 15: 386–394.
  • Lingjaerde O, Ahlfors UG, Bech P, et al. 1987. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl 334: 1–100.
    Direct Link:
  • Little JT, Reynolds CF III, Dew MA, et al. 1998. How common is resistance to treatment in recurrent, nonpsychotic geriatric depression? Am J Psychiatry 155: 1035–1038.
  • Mayberg HS. 2003. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br Med Bull 65: 193–207.
  • Mayberg HS, Liotti M, Brannan SK, et al. 1999. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 156: 675–682.
  • McCormick LM, Ziebell S, Nopoulos P, et al. 2006. Anterior cingulate cortex: an MRI-based parcellation method. Neuroimage 32: 1167–1175.
  • Murphy CF, Gunning-Dixon FM, Hoptman MJ, et al. 2007. White-matter integrity predicts stroop performance in patients with geriatric depression. Biol Psychiatry 61: 1007–1010.
  • Phillips ML, Drevets WC, Rauch SL, et al. 2003. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 54: 504–514.
  • Phillips ML, Ladouceur CD, Drevets WC. 2008. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 13: 833–857.
  • Robertson B, Wang L, Diaz MT, et al. 2007. Effect of bupropion extended release on negative emotion processing in major depressive disorder: a pilot functional magnetic resonance imaging study. J Clin Psychiatry 68: 261–267.
  • Saxena S, Brody AL, Ho ML, et al. 2002. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry 59: 250–261.
  • Seminowicz DA, Mayberg HS, McIntosh AR, et al. 2004. Limbic-frontal circuitry in major depression: a path modeling metanalysis. Neuroimage 22: 409–418.
  • Shrout PE, Fleiss JL. 1979. Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86: 420–428.
  • Smith GS, Reynolds CF III, Pollock B, et al. 1999. Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression. Am J Psychiatry 156: 683–689.
  • Stuss DT, Floden D, Alexander MP, et al. 2001. Stroop performance in focal lesion patients: dissociation of processes and frontal lobe lesion location. Neuropsychologia 39: 771–786.
  • Takami H, Okamoto Y, Yamashita H, et al. 2007. Attenuated anterior cingulate activation during a verbal fluency task in elderly patients with a history of multiple-episode depression. Am J Geriatr Psychiatry 15: 594–603.
  • Vogt BA, Finch DM, Olson CR. 1992. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex 2: 435–443.
  • Whalen PJ, Bush G, McNally RJ, et al. 1998. The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division. Biol Psychiatry 44: 1219–1228.
  • Whyte EM, Basinski J, Farhi P, et al. 2004. Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors. J Clin Psychiatry 65: 1634–1641.
  • Williams JB. 1988. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 45: 742–747.
  • Wu J, Buchsbaum MS, Gillin JC, et al. 1999. Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex. Am J Psychiatry 156: 1149–1158.
  • Zhang Y, Brady M, Smith S. 2001. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 20: 45–57.
Get PDF (138K)