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Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease†
Article first published online: 27 NOV 2009
Copyright © 2009 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 25, Issue 8, pages 780–788, August 2010
How to Cite
Berlow, Y. A., Wells, W. M., Ellison, J. M., Sung, Y. H., Renshaw, P. F. and Harper, D. G. (2010), Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease. Int. J. Geriat. Psychiatry, 25: 780–788. doi: 10.1002/gps.2418
- Issue published online: 7 JUL 2010
- Article first published online: 27 NOV 2009
- Manuscript Accepted: 14 AUG 2009
- Manuscript Received: 28 APR 2009
- NIH. Grant Number: R01 AG020654
- Harvard Center for Neurodegeneration and Repair
- Alzheimer's disease;
- behavioral and psychological symptoms of dementia;
- white matter hyperintensities;
- magnetic resonance imaging;
- Neuropsychiatric Inventory
To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH).
Thirty-seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI-based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes.
Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD.
These findings suggest that white matter changes are associated with the presence of BPSD in AD. Copyright © 2009 John Wiley & Sons, Ltd.