This article was published online on April 14, 2010. An error was subsequently identified in the author's affiliation. This notice is included in the online and print versions to indicate that both have been corrected [May 06, 2010].
The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia†
Article first published online: 14 APR 2010
Copyright © 2010 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 25, Issue 10, pages 1030–1038, October 2010
How to Cite
Larsson, V., Aarsland, D., Ballard, C., Minthon, L. and Londos, E. (2010), The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia. Int. J. Geriat. Psychiatry, 25: 1030–1038. doi: 10.1002/gps.2506
- Issue published online: 14 APR 2010
- Article first published online: 14 APR 2010
- Manuscript Accepted: 8 FEB 2010
- Manuscript Received: 15 NOV 2009
- Swedish Parkinson Academy
- dementia with Lewy bodies;
- Parkinson's disease dementia;
- REM sleep behaviour disorder;
- sleep disorder
Two common and characteristic sleep disturbances have been described in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD); excessive daytime sleepiness and REM sleep behaviour disorder (RBD). This study is an analysis of a secondary outcome measure of a larger study already reported, aimed to determine whether memantine has an effect on the sleep disturbances in DLB and PDD patients.
Patients with DLB or PDD were included in a placebo-controlled, randomised controlled study of memantine (20 mg per day) for 24 weeks. The Stavanger Sleep Questionnaire and the Epworth Sleepiness Scale were used to evaluate the effect on sleep disturbances.
Forty two patients started treatment; 20 with memantine and 22 with placebo. The primary analysis was the comparison of change between the two groups during a 24-week period, using the modified ITT population (last observation carried forward). At 24 weeks, patients treated with memantine were less physically active during sleep while patients in the placebo group worsened. Mean difference between the groups (0.5 [0.05–0.90]) was significant (p = 0.006). No significant change was observed in severity of excessive daytime sleepiness.
Memantine decreases probable REM sleep behaviour disorder in patients with DLB and PDD. Both diagnostic groups contributed equally to the outcome. Copyright © 2010 John Wiley & Sons, Ltd.