Research Article

Subjective memory complaints in community dwelling healthy older people: the influence of brain and psychopathology†

  1. M. Bartley1,*,
  2. A. L. Bokde2,
  3. M. Ewers2,
  4. Y. O. Faluyi5,
  5. W. O. Tobin3,
  6. A. Snow4,
  7. J. Connolly2,
  8. C. Delaney2,
  9. T. Coughlan1,
  10. D. R. Collins1,
  11. H. Hampel2,
  12. D. O'Neill1

Article first published online: 27 SEP 2011

DOI: 10.1002/gps.2794

Issue

Cover image for Vol. 27 Issue 6

Additional Information

How to Cite

Bartley, M., Bokde, A. L., Ewers, M., Faluyi, Y. O., Tobin, W. O., Snow, A., Connolly, J., Delaney, C., Coughlan, T., Collins, D. R., Hampel, H. and O'Neill, D. (2011), Subjective memory complaints in community dwelling healthy older people: the influence of brain and psychopathology. Int. J. Geriat. Psychiatry. doi: 10.1002/gps.2794

Author Information

  1. 1

    Centre for Ageing, Neuroscience and the Humanities, Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital, Ireland

  2. 2

    Discipline of Psychiatry and Trinity College Institute of Neuroscience (TCIN), Trinity College, Dublin, Ireland

  3. 3

    Department of Neurology, Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital, Ireland

  4. 4

    Department of Radiology, Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital, Ireland

  5. 5

    Older People's Services, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK

*Dr. M. Bartley, Centre for Ageing, Neuroscience and the Humanities, Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital, Ireland. E-mail: bartlema@tcd.ie

  1. †

    This manuscript has not been published elsewhere.

Publication History

  1. Article first published online: 27 SEP 2011
  2. Manuscript Accepted: 8 AUG 2011
  3. Manuscript Received: 4 APR 2011

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Keywords:

  • subjective memory complaints;
  • white matter hyperintensities;
  • older

Objectives

Subjective memory complaints (SMC) are common. We aimed to characterize the relationship between psychiatric illness and white matter disease to SMC in a sample of healthy older people.

Measurements

Cognitively normal subjects between 55 and 90 years had age-adjusted and education-adjusted Consortium to Establish a Registry for Alzheimer's disease (CERAD) scores ≤1.5 SD from standard mean. ApoE genotyping was performed using polymerase chain reaction. Sixty subjects (30 SMC, 30 controls) underwent 3T MRI, which was rated by two raters blinded to the diagnosis, for periventricular (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas scale. Subjective memory was assessed by asking the participant, Do you feel like your memory or thinking is becoming worse?

Results

Two hundred and fifteen volunteers were assessed. Ninety-six were cognitively normal (mean age 62.5 years). SMC were reported by 52/96 subjects (54%). These were compared with subjects who denied SMC. Participants with a history of depression or anxiety were more likely to have SMC (p = 0.02). The frequency distribution of ApoE4 allele and CERAD scores were similar. White matter load was similar (p ≤ 0.47), with a high prevalence of PVH and DWMH seen (100% and 88% of scans, respectively).

Conclusion

Both SMC and white matter disease were common. SMC were associated with a history of depression or anxiety but not with white matter disease. Evaluation for a history of depression and anxiety in people with SMC is supported by these findings. Copyright © 2011 John Wiley & Sons, Ltd.

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