Neuroplasticity-based computerized cognitive remediation for geriatric depression
Article first published online: 27 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 27, Issue 12, pages 1239–1247, December 2012
How to Cite
Morimoto, S. S., Wexler, B. E. and Alexopoulos, G. S. (2012), Neuroplasticity-based computerized cognitive remediation for geriatric depression. Int. J. Geriat. Psychiatry, 27: 1239–1247. doi: 10.1002/gps.3776
- Issue published online: 7 NOV 2012
- Article first published online: 27 MAR 2012
- Manuscript Accepted: 5 JAN 2012
- Manuscript Revised: 21 DEC 2011
- Manuscript Received: 18 NOV 2011
- executive function;
- computerized cognitive remediation;
This article describes a novel treatment model designed to target specific neurocognitive deficits in geriatric depression with neuroplasticity-based computerized cognitive remediation (NBCCR).
The recent National Institute of Mental Health (NIMH) report “From Discovery to Cure” calls for studies focusing on mechanisms of treatment response with the goal of arriving at new interventions for those who do not respond to existing treatments. We describe the process that led to the identification of specific executive deficits and their underlying neurobiology, as well as the rationale for targeting these symptoms as a part of a strategy intended to improve both executive dysfunction and depression. We then propose a strategy for further research in this emerging area
Results and Conclusions
Despite significant developments, conventional antidepressant treatments leave many older adults still depressed and suffering. Psychotherapy may be effective in some depressed elders, although a recent review concluded that none of the available treatment studies meets stringent criteria for efficacy in the acute treatment of geriatric depression. Appropriately developed and targeted NBCCR, has the potential to serve as a novel treatment intervention for geriatric depression. Pathophysiological changes associated with executive dysfunction may be an appropriate target for NBCCR. Examining both behavioral changes and indices of structural integrity and functional change of networks related to cognitive and emotional regulation may lead to a novel treatment and elucidate the role of specific cerebral networks in geriatric depression. Copyright © 2012 John Wiley & Sons, Ltd.