Subclinical hypothyroidism, mood, and cognition in older adults: a review
Article first published online: 13 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 28, Issue 2, pages 111–118, February 2013
How to Cite
Joffe, R. T., Pearce, E. N., Hennessey, J. V., Ryan, J. J. and Stern, R. A. (2013), Subclinical hypothyroidism, mood, and cognition in older adults: a review. Int. J. Geriat. Psychiatry, 28: 111–118. doi: 10.1002/gps.3796
- Issue published online: 7 JAN 2013
- Article first published online: 13 MAR 2012
- Manuscript Accepted: 6 FEB 2012
- Manuscript Received: 8 AUG 2011
- subclinical hypothyroidism;
To perform a critical review of the literature on the mood and cognitive changes associated with subclinical hypothyroidism (SCH), with an emphasis on older adults. To evaluate these data against the Consensus Statement on the management of SCH from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society.
A comprehensive literature review.
Subclinical hypothyroidism may be associated with an increased risk of mood and cognitive dysfunction, although the strength of this association and the efficacy of replacement hormone therapy require further investigation.
It remains unclear whether SCH leads to significant mood and cognitive impairments in most older patients. More research is required to determine the nature and extent of this association and whether thyroid hormone replacement therapy is appropriate and effective in treating SCH-associated neurobehavioral impairments. Copyright © 2012 John Wiley & Sons, Ltd.