Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001–2009
Article first published online: 7 MAY 2012
Copyright © 2012 John Wiley & Sons, Ltd.
International Journal of Geriatric Psychiatry
Volume 28, Issue 3, pages 305–311, March 2013
How to Cite
Xiang, Y.-T., Dickerson, F., Kreyenbuhl, J., Ungvari, G. S., Wang, C.-Y., Si, T.-M., Lee, E. H. M., Chiu, H. F. K., Lai, K. Y. C., He, Y.-L., Yang, S.-Y., Chong, M.-Y., Tan, C.-H., Kua, E.-H., Fujii, S., Sim, K., Yong, M. K. H., Trivedi, J. K., Chung, E.-K., Udomratn, P., Chee, K.-Y., Sartorius, N. and Shinfuku, N. (2013), Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001–2009. Int. J. Geriat. Psychiatry, 28: 305–311. doi: 10.1002/gps.3827
- Issue published online: 5 FEB 2013
- Article first published online: 7 MAY 2012
- Manuscript Accepted: 11 APR 2012
- Manuscript Received: 16 DEC 2011
- National Science Foundation of China. Grant Number: No. 30800367; 30770776
- Beijing Nova Program of the Beijing Municipal Science and Technology Commission. Grant Number: No. 2008B59
- Chinese University of Hong Kong. Grant Number: Direct Grant for Research; Project No. 2041454
- Institute of Mental Health Research Grant. Grant Number: CRC 249/2008
- Taiwan Bureau of National Health Insurance. Grant Number: DOH92-NH-1025
- Chang Gung Memorial Hospital. Grant Number: CMRPG83043
- Taipei City Government. Grant Number: 97001-62-010
- prescription patterns;
- older patients;
This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates.
A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients' socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure.
The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications.
Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited. Copyright © 2012 John Wiley & Sons, Ltd.