Cognitive differences among depressed and non-depressed MCI participants: a project FRONTIER study

Authors

  • Leigh A Johnson,

    Corresponding author
    1. Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    • Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    Search for more papers by this author
  • Cortney Mauer,

    1. Department of Psychology, Texas Tech University, Lubbock, TX, USA
    Search for more papers by this author
  • Danielle Jahn,

    1. Department of Psychology, Texas Tech University, Lubbock, TX, USA
    Search for more papers by this author
  • Michael Song,

    1. School of Medicine, Texas Tech University, Lubbock, TX, USA
    Search for more papers by this author
  • Lauren Wyshywaniuk,

    1. Department of Psychology, Texas Tech University, Lubbock, TX, USA
    Search for more papers by this author
  • James R. Hall,

    1. Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    2. Department of Psychiatry and Neuroscience, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    Search for more papers by this author
  • Valerie Hobson Balldin,

    1. Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    2. Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    Search for more papers by this author
  • Sid E. O'Bryant

    1. Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    2. Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA
    Search for more papers by this author

Correspondence to: L. Johnson, PhD, E-mail: leigh.johnson@unthsc.edu

Abstract

Objective

Depression is the most commonly reported psychiatric symptom in patients with mild cognitive impairment (MCI). However, more research is needed examining the impact of depression on cognitive functioning in MCI patients. The purpose of this study was to examine differences in cognitive functioning in a sample of community- based, depressed, and non-depressed MCI patients.

Methods

One hundred and five participants with MCI were included in this study. Participants were recruited from Project FRONTIER, a study of rural health. Depression was assessed via the Geriatric Depression Scale (GDS-30), and cognition was measured using the Repeatable Battery for the Assessment of Neuropsychological Status.

Results

The results indicated that depressed MCI participants performed significantly worse than their non-depressed counterparts on several cognitive measures. MCI participants with depression scored significantly lower on immediate memory (t = 3.4, p < 0.01) and delayed memory (t = 2.8, p < 0.01) indices than their non-depressed counterparts.

Conclusions

The results of this study indicated that MCI participants with depression experienced greater deficits in cognitive functioning than their non-depressed counterparts. Depressed MCI participants exhibited greater deficits in both immediate and delayed memory. Thus, identifying and treating depression in individuals with MCI may improve memory and cognitive functioning. Copyright © 2012 John Wiley & Sons, Ltd.

Ancillary