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Retracted: Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

Authors

  • Yuan Gao,

    1. Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
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  • Changquan Huang,

    1. Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    2. Department of Geriatrics, The third Hospital of Mianyang, Mianyang, Sichuan, China
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  • Kexiang Zhao,

    1. Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
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  • Louyan Ma,

    1. Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    2. Department of Geriatrics, Ninth Hospital of Xi'An, Xi'An, Shanxi, China
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  • Xuan Qiu,

    1. Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, China
    2. Department of Histology and Embryology, Chongqing Medical University, Chongqing, China
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  • Lei Zhang,

    1. Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, China
    2. Department of Histology and Embryology, Chongqing Medical University, Chongqing, China
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  • Yun Xiu,

    1. Institute of Life Science, Chongqing Medical University, Chongqing, China
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  • Lin Chen,

    1. Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, China
    2. Department of Histology and Embryology, Chongqing Medical University, Chongqing, China
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  • Wei Lu,

    1. Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, China
    2. Department of Histology and Embryology, Chongqing Medical University, Chongqing, China
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  • Chunxia Huang,

    1. Department of Physiology, Chongqing Medical University, Chongqing, China
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  • Yong Tang,

    1. Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, China
    2. Department of Histology and Embryology, Chongqing Medical University, Chongqing, China
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  • Qian Xiao

    Corresponding author
    1. Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
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Errata

This article is corrected by:

  1. Errata: Retraction statement: “Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies” by Yuan Gao et al. Volume 30, Issue 4, 435, Article first published online: 6 March 2015

Abstract

Background

This study examined whether depression was a risk factor for onset of dementia including Alzheimer's disease (AD), vascular dementia (VD) and any dementia, and mild cognitive impairment (MCI) by using a quantitative meta-analysis of longitudinal studies.

Methods

EMBASE and MEDLINE were searched for articles published up to February 2011. All studies that examined the relationship between depression and the onset of dementia or MCI were included. Pooled relative risk was calculated using fixed-effects models.

Results

Twelve studies met our inclusion criteria for this meta-analysis. All subjects were without dementia or MCI at baseline. Four, two, five, and four studies compared the incidence of AD, VD, any dementia, and MCI between subjects with or without depression, respectively. After pooling all the studies, subjects with depression had higher incidence of AD (relative risk (RR):1.66, 95% confidence interval (CI): 1.29–2.14), VD (RR: 1.89, 95% CI: 1.19–3.01), any dementia (RR: 1.55, 95% CI: 1.31–2.83), and MCI (RR: 1.97, 95% CI: 1.53–2.54) than those without depression.

Conclusions

The quantitative meta-analysis showed that depression was a major risk factor for incidence of dementia (including AD, VD, and any dementia) and MCI. Copyright © 2012 John Wiley & Sons, Ltd.

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